SC 13D/A

 

 

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

 

 

SCHEDULE 13D/A

(Amendment No. 2)

Under the Securities Exchange Act of 1934

 

 

ALLAKOS INC.

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

01671P100

(CUSIP Number)

John P. McKearn

101 S. Hanley Road, Suite 1850

St. Louis, MO 63105

(314) 726-6700

With copy to:

Gloria M. Skigen, Esq.

Holland & Knight LLP

One Stamford Plaza 263 Tresser Boulevard Suite 1400

Stamford, CT 06901

(203) 905-4526

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

January 4, 2021

(Date of Event which Requires Filing of this Statement)

 

 

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box:  ☐

 

*

The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

 


CUSIP No. 01671P100    13D/A    Page 2 of 26 Pages

 

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Fund II, L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  WC

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  694,669

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  694,669

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  694,669

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  1.3%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

(1)

The percentage set forth in row (13) is based on the 52,503,346 shares of common stock, par value $0.001 per share (“Common Stock”), of Allakos Inc., a Delaware corporation (the “Issuer”), reported by the Issuer to be outstanding as of November 5, 2020 on the Issuer’s Form 10-Q, filed with the Securities and Exchange Commission (“SEC”) on November 9, 2020.

 

2


CUSIP No. 01671P100    13D/A    Page 3 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Fund II (Ohio), L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  WC

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  188,685

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  188,685

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  188,685

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  0.4%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

3


CUSIP No. 01671P100    13D/A    Page 4 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Partners II (Ohio), LLC

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  188,685(2)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  188,685(2)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  188,685(2)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  0.4%(1)

14  

  TYPE OF REPORTING PERSON

 

  OO

 

(2)

Represents 188,685 shares of Common Stock owned by RiverVest Venture Fund II (Ohio), L.P., a Delaware limited partnership (“RiverVest II (Ohio)”). RiverVest Venture Partners II (Ohio), LLC, a Delaware limited liability company (“RiverVest Partners II (Ohio)”), is the general partner of RiverVest II (Ohio).

 

4


CUSIP No. 01671P100    13D/A    Page 5 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Partners II, L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  896,231(3)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  896,231(3)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  896,231(3)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  1.7%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

(3)

Represents 12,877 shares of Common Stock held directly, 694,669 shares of Common Stock owned by RiverVest Venture Fund II, L.P., a Delaware limited partnership (“RiverVest II”), and 188,685 shares of Common Stock owned by RiverVest II (Ohio). RiverVest Venture Partners II, L.P., a Delaware limited partnership (“RiverVest Partners II”), is the general partner of RiverVest II and the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio).

 

5


CUSIP No. 01671P100    13D/A    Page 6 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Partners II, LLC

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  896,231(4)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  896,231(4)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  896,231(4)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  1.7%(1)

14  

  TYPE OF REPORTING PERSON

 

  OO

 

(4)

Represents 12,877 shares of Common Stock owned by RiverVest Partners II, 694,669 shares of Common Stock owned by RiverVest II and 188,685 shares of Common Stock owned by RiverVest II (Ohio). RiverVest Venture Partners II, LLC, a Delaware limited liability company, is the general partner of RiverVest Partners II, which is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio).

 

6


CUSIP No. 01671P100    13D/A    Page 7 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Fund III, L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  WC

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  2,341,594

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  2,341,594

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  2,341,594(5)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  4.5%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

(5)

Includes 1,139,537 shares of Common Stock that are pledged to secure a line of credit pursuant to a customary collateral agreement and promissory note. As of the date of this report, there is no outstanding balance on the line of credit.

 

7


CUSIP No. 01671P100    13D/A    Page 8 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Fund III (Ohio), L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  WC

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  124,275

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  124,275

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  124,275(6)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  0.2%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

(6)

Includes 60,463 shares of Common Stock that are pledged to secure a line of credit pursuant to a customary collateral agreement and promissory note. As of the date of this report, there is no outstanding balance on the line of credit.

 

8


CUSIP No. 01671P100    13D/A    Page 9 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Partners III (Ohio), LLC

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  124,275(7)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  124,275(7)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  124,275(7)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  0.2%(1)

14  

  TYPE OF REPORTING PERSON

 

  OO

 

(7)

Represents 124,275 shares of Common Stock owned by RiverVest Venture Fund III (Ohio), L.P., a Delaware limited partnership (“RiverVest III (Ohio)”). RiverVest Venture Partners III (Ohio), LLC, a Delaware limited liability company (“RiverVest Partners III (Ohio)”), is the general partner of RiverVest III (Ohio).

 

9


CUSIP No. 01671P100    13D/A    Page 10 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Partners III, L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  2,498,721(8)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  2,498,721(8)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  2,498,721(8)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  4.8%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

(8)

Represents 32,852 shares of Common Stock held directly, 2,341,594 shares of Common Stock owned by RiverVest Venture Fund III, L.P., a Delaware limited partnership (“RiverVest III”), and 124,275 shares of Common Stock owned by RiverVest III (Ohio). RiverVest Venture Partners III, L.P., a Delaware limited partnership (“RiverVest Partners III”), is the general partner of RiverVest III and the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio).

 

10


CUSIP No. 01671P100    13D/A    Page 11 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest Venture Partners III, LLC

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  2,498,721(9)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  2,498,721(9)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  2,498,721(9)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  4.8%(1)

14  

  TYPE OF REPORTING PERSON

 

  OO

 

(9)

Represents 32,852 shares of Common Stock owned by RiverVest Partners III, 2,341,594 shares of Common Stock owned by RiverVest III and 124,275 shares of Common Stock owned by RiverVest III (Ohio). RiverVest Venture Partners III, LLC, a Delaware limited liability company, is the general partner of RiverVest Partners III, which is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio).

 

11


CUSIP No. 01671P100    13D/A    Page 12 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  3x5 RiverVest Fund II, L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  WC

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  1,483,103

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  1,483,103

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  1,483,103(10)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  2.8%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

(10)

Includes 1,351,189 shares of Common Stock that are pledged to secure a line of credit pursuant to a customary collateral agreement and promissory note. As of the date of this report, there is no outstanding balance on the line of credit.

 

12


CUSIP No. 01671P100    13D/A    Page 13 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  3x5 RiverVest Fund II-B, L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  WC

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  55,606

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  55,606

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  55,606

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  0.1%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

13


CUSIP No. 01671P100    13D/A    Page 14 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  3x5 RiverVest Partners II, LLC

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  1,538,709(11)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  1,538,709(11)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  1,538,709(11)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  2.9%(1)

14  

  TYPE OF REPORTING PERSON

 

  OO

 

(11)

Represents 1,483,103 shares of Common Stock owned by 3x5 RiverVest Fund II, L.P., a Delaware limited partnership (“3x5 RiverVest II”), and 55,606 shares of Common Stock owned by 3x5 RiverVest Fund II-B, L.P., a Delaware limited partnership (“3x5 RiverVest II-B”). 3x5 RiverVest Partners II, LLC, a Delaware limited liability company (“3x5 RiverVest Partners”), is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B.

 

14


CUSIP No. 01671P100    13D/A    Page 15 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest 3x5 Managers II, L.P.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  1,540,474(12)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  1,540,474(12)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  1,540,474(12)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  2.9%(1)

14  

  TYPE OF REPORTING PERSON

 

  PN

 

(12)

Represents 1,765 shares of Common Stock held directly, 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, and 55,606 shares of Common Stock owned by 3x5 RiverVest II-B. RiverVest 3x5 Managers II, L.P., a Delaware limited partnership (“RiverVest 3x5 Managers”), is one of two members of 3x5 RiverVest Partners, which is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B.

 

15


CUSIP No. 01671P100    13D/A    Page 16 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  RiverVest 3x5 Managers II, LLC

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  Delaware, USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  0

     8   

  SHARED VOTING POWER

 

  1,540,474(13)

     9   

  SOLE DISPOSITIVE POWER

 

  0

   10   

  SHARED DISPOSITIVE POWER

 

  1,540,474(13)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  1,540,474(13)

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  2.9%(1)

14  

  TYPE OF REPORTING PERSON

 

  OO

 

(13)

Represents 1,765 shares of Common Stock owned by RiverVest 3x5 Managers, 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, and 55,606 shares of Common Stock owned by 3x5 RiverVest II-B. RiverVest 3x5 Managers II, LLC, a Delaware limited liability company (“RiverVest 3x5 Managers II”), is the general partner of RiverVest 3x5 Managers, which is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B.

 

16


CUSIP No. 01671P100    13D/A    Page 17 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  John P. McKearn, Ph.D.

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  50,045(14)

     8   

  SHARED VOTING POWER

 

  4,935,426(15)

     9   

  SOLE DISPOSITIVE POWER

 

  50,045(14)

   10   

  SHARED DISPOSITIVE POWER

 

  4,935,426(15)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  4,985,471

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  9.5%(1)

14  

  TYPE OF REPORTING PERSON

 

  IN

 

(14)

In July 2018, the Issuer granted Dr. McKearn, as a non-employee director of the Issuer, an option to purchase 37,600 shares of Common Stock at a per share exercise price equal to $16.00. The option vests as to 1/36th of the shares subject to the option each month following July 2018, subject to continued service through each applicable vesting date. In June 2019, the Issuer granted Dr. McKearn an additional 16,000 options that have fully vested. In May 2020, the Issuer granted Dr. McKearn an additional 7,700 options that have not vested. Dr. McKearn’s options have vested, or will vest within sixty (60) days of the date of this filing, with respect to 49,422 shares of Common Stock.

Also includes 623 shares of Common Stock owned by John McKearn, TOD John and Cassandra McKearn, Trustees of the John P. McKearn Trust dated July 18, 2005, as amended.

 

(15)

Represents 694,669 shares of Common Stock owned by RiverVest II, 188,685 shares of Common Stock owned by RiverVest II (Ohio), 12,877 shares of Common Stock owned by RiverVest Partners II, 2,341,594 shares of Common Stock owned by RiverVest III, 124,275 shares of Common Stock owned by RiverVest III (Ohio), 32,852 shares of Common Stock owned by RiverVest Partners III, 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, 55,606 shares of Common Stock owned by 3x5 RiverVest II-B and 1,765 shares of Common Stock owned by RiverVest 3x5 Managers.

Dr. McKearn is an authorized person of RiverVest Venture Partners II, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners II. RiverVest Partners II is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio).

Dr. McKearn is a member of RiverVest Venture Partners III, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio).

Dr. McKearn is a member of RiverVest 3x5 Managers II, the general partner of RiverVest 3x5 Managers, which in turn is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B.

 

17


CUSIP No. 01671P100    13D/A    Page 18 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  Jay Schmelter

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  1,868(16)

     8   

  SHARED VOTING POWER

 

  4,935,426(17)

     9   

  SOLE DISPOSITIVE POWER

 

  1,868(16)

   10   

  SHARED DISPOSITIVE POWER

 

  4,935,426(17)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  4,937,294

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  9.4%(1)

14  

  TYPE OF REPORTING PERSON

 

  IN

 

(16)

Represents shares of Common Stock owned by RiverVest Venture Management LLC Profit Sharing Plan FBO Jay W. Schmelter.

(17)

Represents 694,669 shares of Common Stock owned by RiverVest II, 188,685 shares of Common Stock owned by RiverVest II (Ohio), 12,877 shares of Common Stock owned by RiverVest Partners II, 2,341,594 shares of Common Stock owned by RiverVest III, 124,275 shares of Common Stock owned by RiverVest III (Ohio), 32,852 shares of Common Stock owned by RiverVest Partners III, 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, 55,606 shares of Common Stock owned by 3x5 RiverVest II-B and 1,765 shares of Common Stock owned by RiverVest 3x5 Managers.

Mr. Schmelter is a member of RiverVest Venture Partners II, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners II. RiverVest Partners II is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio).

Mr. Schmelter is a member of RiverVest Venture Partners III, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio).

Mr. Schmelter is a member of RiverVest 3x5 Managers II, the general partner of RiverVest 3x5 Managers, which in turn is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B.

 

18


CUSIP No. 01671P100    13D/A    Page 19 of 26 Pages

 

  1    

  NAME OF REPORTING PERSON

  I.R.S. IDENTIFICATION NO. (ENTITIES ONLY)

 

  Thomas C. Melzer

  2  

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)  ☐        (b)  ☐

 

  3  

  SEC USE ONLY

 

  4  

  SOURCE OF FUNDS

 

  AF

  5  

  CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

 

  ☐

  6  

  CITIZENSHIP OR PLACE OF ORGANIZATION

 

  USA

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

 

     7     

  SOLE VOTING POWER

 

  6,900(18)

     8   

  SHARED VOTING POWER

 

  4,935,426(19)

     9   

  SOLE DISPOSITIVE POWER

 

  6,900(18)

   10   

  SHARED DISPOSITIVE POWER

 

  4,935,426(19)

11    

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

  4,942,326

12  

  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

 

  ☐

13  

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

  9.4%(1)

14  

  TYPE OF REPORTING PERSON

 

  IN

 

(18)

Includes 3,450 shares of Common Stock owned by the Thomas C. Melzer Revocable Trust dtd 4/4/2002 and 3,450 shares of Common Stock owned by Melzer Family Trust dated 11/9/2006.

(19)

Represents 694,669 shares of Common Stock owned by RiverVest II, 188,685 shares of Common Stock owned by RiverVest II (Ohio), 12,877 shares of Common Stock owned by RiverVest Partners II, 2,341,594 shares of Common Stock owned by RiverVest III, 124,275 shares of Common Stock owned by RiverVest III (Ohio), 32,852 shares of Common Stock owned by RiverVest Partners III, 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, 55,606 shares of Common Stock owned by 3x5 RiverVest II-B and 1,765 shares of Common Stock owned by RiverVest 3x5 Managers.

Mr. Melzer is a member of RiverVest Venture Partners II, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners II. RiverVest Partners II is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio).

Mr. Melzer is a member of RiverVest Venture Partners III, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio).

Mr. Melzer is a member of RiverVest 3x5 Managers II, the general partner of RiverVest 3x5 Managers, which in turn is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B.

 

19


CUSIP No. 01671P100    13D/A    Page 20 of 26 Pages

 

Schedule 13D/A

Pursuant to Rule 13d-2 of Regulation 13D-G of the General Rules and Regulations under the Securities Exchange Act of 1934, as amended, the undersigned hereby amends the statement on Schedule 13D dated September 10, 2018, as amended on May 26, 2020 (the “Schedule 13D”). This Statement constitutes Amendment No. 2 to the Schedule 13D. Unless otherwise indicated herein, there are no material changes to the information set forth in the Schedule 13D.

Except as otherwise provided herein, each Item of the Schedule 13D remains unchanged.

Item 1. Security and Issuer.

No change.

Item 2. Identity and Background.

No change.

Item 3. Source and Amount of Funds or Other Consideration.

On January 4, 2021, RiverVest II, RiverVest II (Ohio), RiverVest III, RiverVest III (Ohio), 3x5 RiverVest II, and 3x5 RiverVest II-B distributed a total of 862,574 shares of Common Stock in kind, without consideration, to its limited partners and general partners.

As a result of the foregoing distributions, the individual Reporting Persons received shares of Common Stock as set forth below:

 

Reporting Person

   Number of Shares  

RiverVest Venture Partners II, LP

     12,877  

RiverVest Venture Partners III, LP

     32,852  

RiverVest 3x5 Managers II, LP

     1,765  

John P. McKearn, Ph.D.

     623  

Jay Schmelter

     1,868  

Thomas C. Melzer

     6,900  

Item 4. Purpose of the Transaction.

No change.

 

20


CUSIP No. 01671P100    13D/A    Page 21 of 26 Pages

 

Item 5. Interest in Securities of the Issuer.

(a) and (b)    

 

Entity or Individual

   Shares
Held
Directly
     Sole
Voting
Power
     Shared
Voting
Power
     Sole
Dispositive
Power
     Shared
Dispositive
Power
     Beneficial
Ownership
     Percentage
of Class(*)
 

RiverVest Venture Fund II, L.P.

     694,669        0        694,669        0        694,669        694,669        1.3

RiverVest Venture Fund II (Ohio), L.P.

     188,685        0        188,685        0        188,685        188,685        0.4

RiverVest Venture Partners II (Ohio), LLC(1)

     0        0        188,685        0        188,685        188,685        0.4

RiverVest Venture Partners II, L.P.(2)

     12,877        0        896,231        0        896,231        896,231        1.7

RiverVest Venture Partners II, LLC(3)

     0        0        896,231        0        896,231        896,231        1.7

RiverVest Venture Fund III, L.P.

     2,341,594        0        2,341,594        0        2,341,594        2,341,594        4.5

RiverVest Venture Fund III (Ohio), L.P.

     124,275        0        124,275        0        124,275        124,275        0.2

RiverVest Venture Partners III (Ohio), LLC(4)

     0        0        124,275        0        124,275        124,275        0.2

RiverVest Venture Partners III, L.P.(5)

     32,852        0        2,498,721        0        2,498,721        2,498,721        4.8

RiverVest Venture Partners III, LLC(6)

     0        0        2,498,721        0        2,498,721        2,498,721        4.8

3x5 RiverVest Fund II, L.P.

     1,483,103        0        1,483,103        0        1,483,103        1,483,103        2.8

3x5 RiverVest Fund II-B, L.P.

     55,606        0        55,606        0        55,606        55,606        0.1

3x5 RiverVest Partners II, LLC(7)

     0        0        1,538,709        0        1,538,709        1,538,709        2.9

RiverVest 3x5 Managers II, L.P.(8)

     1,765        0        1,540,474        0        1,540,474        1,540,474        2.9

RiverVest 3x5 Managers II, LLC(9)

     0        0        1,540,474        0        1,540,474        1,540,474        2.9

John P. McKearn, Ph.D.(10)

     50,045        50,045        4,935,426        50,045        4,935,426        4,985,471        9.5

Jay Schmelter(11)

     1,868        1,868        4,935,426        1,868        4,935,426        4,937,294        9.4

Thomas C. Melzer(12)

     6,900        6,900        4,935,426        6,900        4,935,426        4,942,326        9.4

 

 

21


CUSIP No. 01671P100    13D/A    Page 22 of 26 Pages

 

(*)

Based on the 52,503,346 shares of Common Stock reported by the Issuer to be outstanding as of November 5, 2020 on the Issuer’s Form 10-Q, filed with the SEC on November 9, 2020.

(1)

RiverVest Partners II (Ohio), as the general partner of RiverVest II (Ohio), may be deemed to beneficially own the 188,685 shares of Common Stock owned by RiverVest II (Ohio).

(2)

RiverVest Partners II is the general partner of RiverVest II and the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio), and as a result,, may be deemed to beneficially own the 694,669 shares of Common Stock owned by RiverVest II and the 188,685 shares of Common Stock owned by RiverVest II (Ohio).

(3)

RiverVest Venture Partners II, LLC, a Delaware limited liability company, is the general partner of RiverVest Partners II, which is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio), and as a result, may be deemed to beneficially own the 12,877 shares of Common Stock owned by RiverVest Partners II, the 694,669 shares of Common Stock owned by RiverVest II and the 188,685 shares of Common Stock owned by RiverVest II (Ohio).

(4)

RiverVest Partners III (Ohio) is the general partner of RiverVest III (Ohio), and as a result, may be deemed to beneficially own the 124,275 shares of Common Stock owned by RiverVest III (Ohio).

(5)

RiverVest Partners III is the general partner of RiverVest III and the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio), and as a result, may be deemed to beneficially own the 2,341,594 shares of Common Stock owned by RiverVest III and the 124,275 shares of Common Stock owned by RiverVest III (Ohio).

(6)

RiverVest Venture Partners III, LLC, a Delaware limited liability company, is the general partner of RiverVest Partners III, which is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio), and as a result, may be deemed to beneficially own the 32,852 shares of Common Stock owned by RiverVest Partners III, the 2,341,594 shares of Common Stock owned by RiverVest III and the 124,275 shares of Common Stock owned by RiverVest III (Ohio).

(7)

3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B, and as a result, may be deemed to beneficially own the 1,483,103 shares of Common Stock owned by 3x5 RiverVest II and the 55,606 shares of Common Stock owned by 3x5 RiverVest II-B.

(8)

RiverVest 3x5 Managers is one of two members of 3x5 RiverVest Partners, which is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B, and as a result, may be deemed to beneficially own the 1,483,103 shares of Common Stock owned by 3x5 RiverVest II and the 55,606 shares of Common Stock owned by 3x5 RiverVest II-B.

(9)

RiverVest 3x5 Managers II is the general partner of RiverVest 3x5 Managers, which is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B. As a result, RiverVest 3x5 Managers II may be deemed to beneficially own the 1,765 shares of Common Stock owned by RiverVest 3x5 Managers, the 1,483,103 shares of Common Stock owned by 3x5 RiverVest II and the 55,606 shares of Common Stock owned by 3x5 RiverVest II-B.

(10)

Dr. McKearn is an authorized person of RiverVest Venture Partners II, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners II. RiverVest Partners II is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio). As a result, Dr. McKearn may be deemed to beneficially own the 694,669 shares of Common Stock owned by RiverVest II, the 188,685 shares of Common Stock owned by RiverVest II (Ohio) and the 12,877 shares of Common Stock owned by RiverVest Partners II.

Dr. McKearn is a member of RiverVest Venture Partners III, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio). As a result, Dr. McKearn may be deemed to beneficially own the 2,341,594 shares of Common Stock owned by RiverVest III, the 124,275 shares of Common Stock owned by RiverVest III (Ohio) and the 32,852 shares of Common Stock owned by RiverVest Partners III.

Dr. McKearn is a member of RiverVest 3x5 Managers II, the general partner of RiverVest 3x5 Managers, which in turn is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B. As a result, Dr. McKearn may be deemed to beneficially own the 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, the 55,606 shares of Common Stock owned by 3x5 RiverVest II-B and the 1,765 shares of Common Stock owned by RiverVest 3x5 Managers.

 

22


CUSIP No. 01671P100    13D/A    Page 23 of 26 Pages

 

In addition, in July 2018, the Issuer granted Dr. McKearn, as a non-employee director of the Issuer, an option to purchase 37,600 shares of Common Stock at a per share exercise price equal to $16.00. The option vests as to 1/36th of the shares subject to the option each month following July 2018, subject to continued service through each applicable vesting date. In June 2019, the Issuer granted Dr. McKearn an additional 16,000 options that have fully vested. In May 2020, the Issuer granted Dr. McKearn an additional 7,700 options that have not vested. Dr. McKearn’s options have vested, or will vest within sixty (60) days of the date of this filing, with respect to 49,422 shares of Common Stock.

 

(11)

Mr. Schmelter is a member of RiverVest Venture Partners II, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners II. RiverVest Partners II is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio).    As a result, Mr. Schmelter may be deemed to beneficially own the 694,669 shares of Common Stock owned by RiverVest II, the 188,685 shares of Common Stock owned by RiverVest II (Ohio) and the 12,877 shares of Common Stock owned by RiverVest Partners II.

Mr. Schmelter is a member of RiverVest Venture Partners III, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio). As a result, Mr. Schmelter may be deemed to beneficially own the 2,341,594 shares of Common Stock owned by RiverVest III, the 124,275 shares of Common Stock owned by RiverVest III (Ohio) and the 32,852 shares of Common Stock owned by RiverVest Partners III.

Mr. Schmelter is a member of RiverVest 3x5 Managers II, the general partner of RiverVest 3x5 Managers, which in turn is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B. As a result, Mr. Schmelter may be deemed to beneficially own the 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, the 55,606 shares of Common Stock owned by 3x5 RiverVest II-B and the 1,765 shares of Common Stock owned by RiverVest 3x5 Managers.

 

(12)

Mr. Melzer is a member of RiverVest Venture Partners II, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners II. RiverVest Partners II is (a) the general partner of RiverVest II and (b) the sole member of RiverVest Partners II (Ohio), which is the general partner of RiverVest II (Ohio). As a result, Mr. Melzer may be deemed to beneficially own the 694,669 shares of Common Stock owned by RiverVest II, the 188,685 shares of Common Stock owned by RiverVest II (Ohio) and the 12,877 shares of Common Stock owned by RiverVest Partners II.

Mr. Melzer is a member of RiverVest Venture Partners III, LLC, a Delaware limited liability company, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio).    As a result, Mr. Melzer may be deemed to beneficially own the 2,341,594 shares of Common Stock owned by RiverVest III, the 124,275 shares of Common Stock owned by RiverVest III (Ohio) and the 32,852 shares of Common Stock owned by RiverVest Partners III.

Mr. Melzer is a member of RiverVest 3x5 Managers II, the general partner of RiverVest 3x5 Managers, which in turn is one of two members of 3x5 RiverVest Partners. 3x5 RiverVest Partners is the general partner of 3x5 RiverVest II and 3x5 RiverVest II-B. As a result, Mr. Melzer may be deemed to beneficially own the 1,483,103 shares of Common Stock owned by 3x5 RiverVest II, the 55,606 shares of Common Stock owned by 3x5 RiverVest II-B and the 1,765 shares of Common Stock owned by RiverVest 3x5 Managers.

By virtue of the relationships described herein, the Reporting Persons may be deemed to constitute a “group” for purposes of Section 13(d)(3) of the Act. The filing of this Statement shall not be construed as an admission that the Reporting Persons are a group, or have agreed to act as a group. Each Reporting Person expressly disclaims beneficial ownership of the securities reported herein, except to the extent such Reporting Person actually exercises voting or dispositive power with respect to such securities.

(c) Except as set forth herein, none of the Reporting Persons has effected any transactions in the shares of the Issuer’s Common Stock during the last 60 days.

(d) No change.

(e) No change.

 

23


CUSIP No. 01671P100    13D/A    Page 24 of 26 Pages

 

Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.

No change.

Item 7. Material to be Filed as Exhibits.

 

Exhibit A:    Joint Filing Agreement, dated September 10, 2018, by and among the Reporting Persons.*

 

*

Previously filed.

 

24


CUSIP No. 01671P100    13D/A    Page 25 of 26 Pages

 

SIGNATURES

After reasonable inquiry and to the best of our knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.

January 8, 2021

 

RiverVest Venture Fund II, L.P.       RiverVest Venture Fund II (Ohio), L.P.
By:    RiverVest Venture Partners II, L.P.,       By:    RiverVest Venture Partners II (Ohio), LLC,
   its general partner          its general partner
By:    RiverVest Venture Partners II, LLC,       By:    RiverVest Venture Partners II, L.P.,
   its general partner          its sole member
                  By:    RiverVest Venture Partners II, LLC,
By:   

/s/ John P. McKearn

         its general partner
   Name: John P. McKearn, Ph.D.         
   Title:   Authorized Person       By:   

/s/ John P. McKearn

            Name: John P. McKearn, Ph.D.
            Title:   Authorized Person
RiverVest Venture Partners II (Ohio), LLC       RiverVest Venture Partners II L.P.
By:    RiverVest Venture Partners II, L.P.,       By:    RiverVest Venture Partners II, LLC,
   its sole member          its general partner
By:    RiverVest Venture Partners II, LLC,         
   its general partner       By:   

/s/ John P. McKearn

            Name: John P. McKearn, Ph.D.
By:   

/s/ John P. McKearn

         Title:   Authorized Person
   Name: John P. McKearn, Ph.D.         
   Title:   Authorized Person         
RiverVest Venture Partners II, LLC       RiverVest Venture Fund III, L.P.
By:   

/s/ John P. McKearn

      By:    RiverVest Venture Partners III, L.P.,
   Name: John P. McKearn, Ph.D.          its general partner
   Title:   Authorized Person       By:    RiverVest Venture Partners III, LLC,
            its general partner
         By:   

/s/ John P. McKearn

            Name: John P. McKearn, Ph.D.
            Title:   Member
RiverVest Venture Fund III (Ohio), L.P.       RiverVest Venture Partners III (Ohio), LLC
By:    RiverVest Venture Partners III (Ohio), LLC,       By:    RiverVest Venture Partners III, L.P.,
   its general partner          its sole member
By:    RiverVest Venture Partners III, L.P.,       By:    RiverVest Venture Partners III, LLC,
   its sole member          its general partner
By:    RiverVest Venture Partners III, LLC,         
   its general partner       By:   

/s/ John P. McKearn

            Name: John P. McKearn, Ph.D.
By:   

/s/ John P. McKearn

         Title:   Member
   Name: John P. McKearn, Ph.D.         
   Title:   Member         

 

[Signature Page of Schedule 13D/A]


CUSIP No. 01671P100    13D/A    Page 26 of 26 Pages

 

RiverVest Venture Partners III, L.P.      RiverVest Venture Partners III, LLC
By:   RiverVest Venture Partners III, LLC,      By:   

/s/ John P. McKearn

  its general partner         Name: John P. McKearn, Ph.D.
          Title:   Member
By:  

/s/ John P. McKearn

       
  Name: John P. McKearn, Ph.D.                 
  Title:   Member        
3x5 RiverVest Fund II, L.P.      3x5 RiverVest Fund II-B, L.P.
By:   3x5 RiverVest Partners II, LLC,      By:    3x5 RiverVest Partners II, LLC,
  its general partner         its general partner
By:   RiverVest 3x5 Managers II, L.P.,      By:    RiverVest 3x5 Managers II, L.P.,
  its member         its member
By:   RiverVest 3x5 Managers II, LLC,      By:    RiverVest 3x5 Managers II, LLC,
  its general partner         its general partner
By:  

/s/ John P. McKearn

     By:   

/s/ John P. McKearn

  Name: John P. McKearn, Ph.D.         Name: John P. McKearn, Ph.D.
  Title:   Member         Title:   Member
3x5 RiverVest Partners II, LLC      RiverVest 3x5 Managers II, L.P.
By:   RiverVest 3x5 Managers II, L.P.,      By:    RiverVest 3x5 Managers II, LLC,
  its member         its general partner
By:   RiverVest 3x5 Managers II, LLC,        
  its general partner      By:   

/s/ John P. McKearn

          Name: John P. McKearn, Ph.D.
By:  

/s/ John P. McKearn

        Title:   Member
  Name: John P. McKearn, Ph.D.        
  Title:   Member        
RiverVest 3x5 Managers II, LLC        
By:  

/s/ John P. McKearn

    

/s/ John P. McKearn

  Name: John P. McKearn, Ph.D.      John P. McKearn, Ph.D.
  Title:   Member     

/s/ Jay Schmelter

    

/s/ Thomas C. Melzer

Jay Schmelter      Thomas C. Melzer

[Signature Page of Schedule 13D/A]